The Animated Atlas of Neuropathic Pain features engaging visuals that illustrate the neuronal, cellular, and molecular mechanisms underlying neuropathic pain, diabetic neuropathy, and neuralgia. It also explores treatment options, including drug therapy and nerve stimulation, all presented through captivating and lifelike animations.
Table of contents
1. Neurobiology of pain
1. Neurotransmitters – Peptides, excitatory amino acids, nitric oxide
2. Peripheral pain mediators
3. Prostaglandin E2 (PGE2) as CNS and bradykinin as peripheral pain mediators or modulators
4. Substance P and feed-forward inhibition
5. Cellular and molecular mechanisms of pain
6. Chemokines as pain mediators and modulators
7. Neurotrophins: mediators and modulators of pain
8. Immune and glial cell factors as pain mediators and modulators
9. Pro-inflammatory cytokines
10. Role of non-neuronal cell factors
11. Glial activation
12. Neuroanatomy of pain perception - the supraspinal network & noxious sensory stimuli
13. Pain pathways – ascending & descending pathways; Gate control
14. Plasticity of pain-related neuronal activity in the thalamus; role of the dorsal horn
15. The genetics of pain
16. Autonomic-endocrine-immune interactions in acute and chronic pain
17. Placebo analgesia
2. Migraine - risk factors, complications, diagnosis and treatment
1. Peripheral nerve injury and neuropathic pain
2. Neuronal (including brain imaging) and molecular mechanisms in neuropathic pain
3. Phantom limb pain
4. Postherpetic neuralgia
5. Diabetic neuropathy
6. Allodynia
7. Hyperpathia
8. Neurotrophic factors
9. Role of sodium channels
10. Changes in hypothalamo-pituitary-adrenal (HPA) axis
11. Role of microglial cell in the pathogenesis of neuropathic pain
12. Ectopic nerve impulse generation
13. Neurotrophic factor treatment for neuropathic pain
14. Ectopic nerve impulse suppression – role of gabapentin
15. Anticonvulsants for neuropathic pain
16. Tricyclic antidepressants
17. Stimulation - Spinal cord and brain stimulation
18. Implantable intrathecal drug delivery systems
19. Sodium channel blockers